Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC

Self-assembly of amyloid proteins and peptides into fibrils is usually associated with many humane diseases such as Alzheimer's, Parkinson's type 2 diabetes. Functional amyloids bacterial amyloids, on the other hand, also have vital functions including strengthening attachment to surfaces enhancing stability stiffness biofilms. FapC precursor protein a functional expressed in Pseudomonas. sequence comprised repeat motifs that are separated by linker highly conserved among genera, which been postulated play important roles formation, but little known about their exact fibrillization process. addition, it not clear whether can “cross-seed” formation pathological Abeta aggregation Alzheimer's disease. Here, we performed atomistic discrete molecular dynamic simulations several constructs different combinations motifs. We confirmed these form beta-sheet rich structures crucial role provided computational evidence has amyloidogenic regions interact via forming structures. Pre-formed nano-fibril constructed one act seed accelerate aggregation, helps understand correlation between two diseases.